The Große Schweimke is a river of Lower Saxony, Germany.
It is long and a tributary of the Kleine Steinau, north of Herzberg am Harz in the district of Göttingen. It rises at about 602 m above sea level and south of the Schindelkopf and roughly north of the Weinbergstraße road on the ridge known as Auf dem Acker. It flows initially in a southwesterly direction before swinging west and discharging into the Kleine Steinau.
See also List of rivers of Lower Saxony
Sources Topographische Karte 1:25000, Nr. 4228 Riefensbeek (source) Topographische Karte 1:25000, Nr. 4227 Osterode im Harz (mouth)