Titone is an Italian surname. Notable people with the surname include:
Brianna Titone, American politician Mario Titone (born 1988), Italian footballer Matthew Titone, American politician Jackie Sandler née Titone, American actress and model Joseph F. Titone, American politician from New Hampshire Joseph H. Titone (born 1946), American politician from Florida Claudio Titone, notable Italian Installation Coordinator which has led successful offshore campaigns all around the globe
See also Tithonus, from Greek mythology, known in Italian as Titone