SPSS is a statistical analysis software.

SPSS may also refer to:

SPSS Inc., company Narco sub, self-propelled semi-submersible Science Planning and Scheduling System, module of the Hubble Space Telescope Special State Protection Service of Georgia, the state protection agency of Georgia

Organizations Sree Pushpakabrahmana Seva Sangham, Kerala, India

Schools St. Paul's Secondary School, Hong Kong St. Peter's Secondary School (disambiguation) South Peace Secondary School, Dawson Creek, British Columbia