Mattison is a surname. Notable people with the surname include:
Alexander Mattison (born 1998), American football player Alice Mattison, American novelist and short story writer Andrew Mattison (1948–2005), medical psychologist and researcher Bryan Mattison (born 1984), American football guard Donald Mattison (1905–1975), American artist Greg Mattison (born 1949), American football coach Harry Mattison (born 1948), American photographer Jenna Mattison (born 1976), American actress, screenwriter and producer Landy Mattison (born 1983), American soccer defender Mike Mattison, American musician and the lead vocalist of The Derek Trucks Band Tyler Mattison (born 1999), American baseball player
See also Keasbey and Mattison Company, manufacturing company that produced asbestos and related building products before being purchased by Turner & Newall in 1934