McBrien is a surname of Irish origin that is an anglicization of Mac Briain ("son of Brian"). Notable people with the surname include:
Fred McBrien (1888–1938), Canadian lawyer, businessman, and politician James McBrien (1869–1958), British police officer and detective Likely McBrien (1892–1956), leading Australian rules football administrator Richard McBrien (1936–2015), the Crowley-O'Brien Professor of Theology at the University of Notre Dame Scott McBrien (born 1980), former American football quarterback William C. McBrien (1889–1954), Canadian business owner and civic administrator
See also Donnchad mac Briain (died 1064), son of Brian Bóruma and Gormflaith ingen Murchada, King of Munster William McBrien Building, the administrative headquarters of the Toronto Transit Commission MacBrien
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