Darst is a surname. Notable people with the surname include:
David Darst, CFA, an American financier, educator and author Jeanne Darst, American author Joseph Darst (1889–1953), the thirty-seventh Mayor of St. Louis Margaret Darst Corbett (1889–1962), American vision educator who used the discredited Bates method Seth Darst, American biochemist, member of the United States National Academy of Sciences