Lisco may refer to one of the following:
Lisco, Nebraska, a census-designated place in the United States Lisco State Aid Bridge, listed on National Register of Historic Places Adrian Esquino Lisco (died 2007), El Salvadoran activist Emil Gustav Lisco (1819-1887), German Protestant minister Friedrich Gustav Lisco (1791-1866), German Protestant theologian Libyan Iron and Steel Company, a Libyan steelmaker