George Sykes (1822–1880) was an American Civil War major general in the Union Army.
George Sykes may also refer to: George Sykes (footballer) (born 1994), English/Scottish footballer George Sykes (New Hampshire politician) (born 1951), member of the New Hampshire House of Representatives George Sykes (New Jersey politician) (1802–1880), U.S. Representative from New Jersey George Sykes (New Zealand politician) (1867–1957), New Zealand Member of Parliament George Sykes (Wisconsin politician) (1816–1881), member of the Wisconsin State Assembly
See also Sykes (disambiguation)