Cruella can refer to:
Cruella de Vil, a character in the 101 Dalmatians novel, three films, and animated series Cruella (film), a live-action crime film based on the Disney animated character Cruella (soundtrack), the soundtrack album to the film of the same name Cruella, a fetish magazine Krewella, an American electronic dance music group
People Agustín Cruella (1897–1968), Spanish footballer