Custódio or Custodio is both a given name and surname of Portuguese origin. Notable people with the name include:
Given name Custódio Castro (born 1983), Portuguese football midfielder Custodio Dos Reis (1922–1959), French road bicycle racer Custódio Ezequiel (born 1962), Portuguese sport shooter Custodio García Rovira (1780–1816), Neogranadine general, statesman and painter Custódio José de Melo (1840–1902), Brazilian naval officer and politician Custódio Muchate (born 1982), Mozambican basketball player Custódio Alvim Pereira (1915–2006), Portuguese clergyman, Archbishop of Lourenço Marques in Mozambique Custódio Pinto (1942–2004), Portuguese footballer
Surname Adriano Tomás Custodio Mendes (born 1961), Cape Verdean footballer of Portuguese nationality Ana María Custodio (1908–1976), Spanish film actress Bonbon Custodio (born 1982), Filipino basketball player Denílson Custódio Machado (born 1943), Brazilian football defensive midfielder and manager Maestro Custodio (14th-century), Benedictine monk living in the city of Oviedo in Asturias, Spain Mário Custódio Nazaré (born 1976), Brazilian footballer Olivier Custodio (born 1995), Swiss football midfielder Olga E. Custodio (born 1954), United States Air Force officer