Mayuko (written: , , , , or ) is a feminine Japanese given name. Notable people with the name include:

, Japanese actress and voice actress , Japanese model, actress and entertainer , Japanese synchronized swimmer and coach , Japanese actress Mayuko Goto (born 1995), Japanese freestyle swimmer , Japanese racing cyclist , Japanese formel idol of idol group Super Girls , Japanese actress and model , Japanese handball player , Japanese entertainer, model and actress , Japanese violinist , Japanese-American actress , Japanese voice actress , Japanese entertainment reporter Mayuko Kitayama (born 1984), Japanese backup dancer , Japanese actress , Japanese politician , Japanese announcer and news anchor , Japanese journalist and media scholar , Japanese mathematician and mathematical physicist

Fictional characters Mayuko Kiyokawa, a character from Soar High! Isami , a character from Ushio and Tora