Hardison is a surname. Notable people with the surname include:
Benjamin Hardison (1761–1823), farmer, miller and political figure in Upper Canada Bethann Hardison, American model Casey William Hardison (born 1971), American chemist Dee Hardison (1956–2018), American football player Harold Hardison (1923–2015), American politician from North Carolina Kadeem Hardison (born 1965), American actor Marcus Hardison (born 1992), American football player Wallace Hardison (1850–1909), co-founder of Union Oil
Fictional characters: Alec Hardison, hacker in the TV series Leverage
See also O. B. Hardison Jr. Poetry Prize, American poetry prize