El Guapo (Spanish for "The Handsome") or Guapo may refer to:
Arts and entertainment El Guapo (band), later Supersystem, an American band Guapo (band), a British art rock band El Guapo, a Marvel Comics character in the superhero team X-Statix El Guapo, a fictional character and the main antagonist in the 1986 film Three Amigos El Guapo, gaming alias of the young Sylvester Dodd in Scorpion (TV series). First mentioned in season 1, episode 13 - “Kill Screen.”
Nickname or stage name Rich Garcés (born 1971), American baseball pitcher David Guapo, David Callejón (born 1981), Spanish comedian and singer Bas Rutten (born 1965), Dutch-American actor and MMA fighter
Places El Guapo, Miranda, Venezuela Guapo River, Venezuela Guapo, a village in Point Fortin, Trinidad and Tobago