First Baptist Church is a historic Baptist church affiliated with the Cooperative Baptist Fellowship located at Middle Street and Church Alley in New Bern, Craven County, North Carolina. It was built in 1848, and is a rectangular brick church building in the Gothic Revival style. It features a two-stage, turreted entrance tower. Its brickwork is laid in Flemish bond.

It was listed on the National Register of Historic Places in 1972.

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