The Netherlands Football League Championship 1942–1943 was contested by 52 teams participating in five divisions. The national champion would be determined by a play-off featuring the winners of the eastern, northern, southern and two western football divisions of the Netherlands. ADO won this year's championship by beating Feijenoord, Willem II, SC Enschede and Heerenveen.
New entrants Eerste Klasse East: Promoted from 2nd Division: Go Ahead Eerste Klasse South: Promoted from 2nd Division: Maurits Eerste Klasse West-I: Moving in from West-II: HBS Craeyenhout, Hermes DVS and Sparta Rotterdam Promoted from 2nd Division: De Volewijckers Eerste Klasse West-II: Moving in from West-I: AFC Ajax, Feijenoord and VUC
Divisions
Eerste Klasse East
Eerste Klasse North
Eerste Klasse South
Eerste Klasse West-I
Eerste Klasse West-II
Championship play-off
References RSSSF Netherlands Football League Championships 1898-1954 RSSSF Eerste Klasse Oost RSSSF Eerste Klasse Noord RSSSF Eerste Klasse Zuid RSSSF Eerste Klasse West