Eugene O'Brien may refer to:
Eugene O'Brien (actor) (1880–1966), American silent film and stage actor Eugene O'Brien (composer) (born 1945), American composer, and professor Eugene O'Brien (engineer) Irish bridge engineer and academic Eugene O'Brien (playwright), Irish playwright, screenwriter and actor Eugene O'Brien (politician) (1897–1980), Irish politician Eugene O'Brien (racing driver) (born 1960), British auto racing driver and coach Eugene W. O'Brien (1897–1970s), American engineer, editor, and publisher