PLO is the Palestine Liberation Organization, an organization for the creation of the independent State of Palestine.
PLO may also refer to:
Pot Limit Omaha, a poker variant People's Law Office, a law office in America Plo Koon, a fictional character in Star Wars Port Lincoln Airport Pregnancy- and lactation-associated osteoporosis, a rare form of osteoporosis Pulgaon railway station (station code: PLO), Maharashtra, India
See also PL/0, a computer programming language