Eileen O'Brien may refer to:
Eileen O'Brien (actress), English actress Eibhlín Ní Bhriain (1925–1986), also published as Eileen Mary O'Brien, Irish journalist Eileen O'Brien (baseball) (1922–2015), played in the All-American Girls Professional Baseball League in 1946 Eileen Quiring O'Brien (born 1948), American politician in Washington, and in Oregon Eileen O'Brien, musician, daughter of accordionist Paddy O'Brien
See also Aileen O'Brien (1913–2000), American writer, journalist, and political activist