Patrizia Paterlini-Bréchot, born in the Italian city of Reggio Emilia, is an Italian scientist and a professor of cell biology and oncology working at the Faculté de Médecine Necker-Enfants Malades, Université Paris Descartes and at INSERM in Paris.

Education Patrizia Paterlini-Bréchot studied medicine at the University of Modena and Reggio Emilia, Italy. In 1978, she defended a thesis on Hodgkin's Lymphoma, which was awarded the title of « Best medical thesis » of the year 1978. She pursued her training and validated a double specialization in Hematology (1981), awarded the prize of « Best research in Hematology » of the year 1979, and in Oncology (1984). Patrizia Paterlini-Bréchot obtained a permanent academic position in the University of L'Aquila (1981), then Bologna (1984) working in the departments of Hematology, Gastroenterology and Oncology. In 1988 she moved to Paris (France) for a training in molecular biology in professor Christian Bréchot's laboratory. In 1993, she defended her PhD thesis, Fundamental bases of oncogenesis at University of Paris XI. She quit her academic position in the University of Bologna in 1993 and in 1994 she obtained an equivalent position in Paris Descartes University in Paris.

Research In 1994, she demonstrated the clinical impact of a new marker of cell proliferation, cyclin A, discovered in the same laboratory. In 1995, she was awarded the Prize of Scientific excellence Assistance Publique – Hôpitaux de Paris. Her work in Christian Brechot's team demonstrated the pro-carcinogenic impact"Identification and functional characterization of a new member of the human Mcm protein family: hMcm8" by Patrizia Paterlini-Bréchot . Scientific Commons website. of hepatitis B Virus (HBV) genome integration into cellular DNA both in patients having serological markers of HBV infection and in patients lacking serological markers but having persistence of the HBV DNA in their liver. The work of her team thus demonstrated a mechanism involved in the direct tumorigenic effect of this virus. In 2004 she was appointed full professor of cell biology in the same university. With her team, she published studies showing the primary role of calcium signalling deregulation in HBV and Hepatitis C virus (HCV) – related liver oncogenesis and in pathologies related to ER stress. From 2002 to 2006 she served as interim Director of INSERM Unit 370, previously directed by professor Christian Bréchot. In 2006, she was appointed Director of INSERM Unit 807.. Paris V University website, Inserm. In addition to fundamental research studies, her activity has been focused to clinically applied research, targeting the domains of predictive oncology and non-invasive prenatal diagnosis.

The ISET technique

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The work of Patrizia Paterlini-Bréchot led to the discovery of the ISET testThe first program about the ISET technique has been seen of french television, France 5 canal, 10 February 2009, "Reportage France 5 sur le diagnostic prénatal non-invasif" . CIANE Website. permitting the isolation and characterization of both circulating tumor and fetal cells. This discovery led Patrizia Paterlini-Bréchot to found her own company named Rarecells Diagnostics"Rarecells official website". to develop the ISET technique.

Major publications P. Paterlini, M. Coppo, Metodologia diagnostica, Piccin Publishing, Padova, Italy, 1987.

Articles

Paterlini P., E. Manzini, P. Neri, U. Torelli : The Castleman lymphopathy : cytochemical and immunocytochemical analysis of ten cases. In Haematologica, 60, 123–132, 1979. Mauri C, Paterlini P : Histological and immunohistochemical characterization of lymphomatous extranodal localizations. In Haematologica, 63, 344–356, 1980. Ponz de Leon, P. Paterlini, A. Caroleo, N. Carulli : Serum cholesterol levels and lipoprotein cholesterol in liver cirrhosis. Ital. J. Gastroenterol., 13, 167–171, 1981. P Paterlini, D. Quaglino, A. de Pasquale, G. Cretara, L. Venturoni : Chronic lymphocytic leukaemia associated to multiple myeloma. In Haematologica, 67, 576–588, 1982. De Pasquale, P. Paterlini, M. Ricciotti, D. Quaglino : Cytoenzymatic staining patterns of malignant lymphoid T cells. In Basic and Applied Histochemistry. Suppl. 26, 133–136,1982. De Pasquale, P. Paterlini, D. Quaglino : Immunochemical demonstration of different antigens in single cells in paraffin-embedded histological sections. In Clin. Lab. Haemat. 4, 267–270, 1982. P Paterlini, M. Ricciotti, G. Cretara, E. D'Allessandro, A Franchi, D. Quaglino : Cytobiological studies and pathogenetic speculations in an atypical case of Sézary syndrome. In Haematologica, 68, 581–590, 1983. De Pasquale, P Paterlini, Daniela Quaglino, D. Quaglino : Emperipolesis of granulocytes within megakaryocytes. Br. J. Haematol., 60, 384–386, 1985. P Paterlini, L. Venturoni, G. Cretara, M. Ricciotti, D. Quagliano : Bone marrow necrosis : an unusual presenting feature of small cell lung carcinoma. In Tumori, 71, 403–406, 1985. De Pasquale, P. Paterlini, A. Di Francesco, L. Vecchio, D. Quaglino : Follicular lymphomas with predominant splenic involvement : report of two cases. In Tumori, 72, 109–115, 1986. De Pasquale, L. Venturoni, P. Paterlini, G. Cretara, A. Di Francesco, D. Quaglino : Possible usefulness of ticlopidine in combined treatment of thrombotic thrombocytopenic purpura. In Haematologica, 71, 53–55, 1986. P Paterlini, E. D'Alessandro, L. Menaguale, M.L. Lo Re, G. Del Porto, D. Quaglino : Unusual interstitial deletion of 8q12 band in a case of acute monocytic leukaemia. In A critical region in haematological malignancies. Tumori, 73, 437–443, 1987. Paterlini, E. Pisi : Oncologic news : the oncogenes, Il Fegato 32, 213–231, 1986. D'Alessandro, P. Paterlini, ML Lo Re, M. Di Cola, C. Ligas, D. Quaglino, G. Del Porto, Cytogenetic follow up in a case of Sézary Syndrome. In Cancer Genet. Cytogenet. , 45, 231–236, 1990. Paterlini P., Gerken G., Nakajima E., Terré S., D'Errico A., Grigioni W., Nalpas B., Wands J., Kew M., Pisi E., Tiollais P., Bréchot C., Polymerase chain reaction for detection of hepatitis B virus DNA and RNA sequences in hepatitis B surface antigen negative patients with primary liver cancer : a study in high and low endemic areas. In N. Engl. J. Med. 323, 80–85, 1990. Paterlini P., Lallement-Le Coeur S., Lallement M., Pelé P.M., Dazza M.C., Terré S., Moncany M., Jourdain G., Courgnaud V., N'Zingoula S., Larouzé B., Griscelli C., Bréchot C., Polymerase chain reaction for studies of mother to child transmission of HIV1, in Africa. J. Med. Virol. 30, 53–57, 1990. Paterlini P., Gerken G., Khemeny F., Franco D., D'Errico A., Grigioni W., Wands J., Kew M., Pisi E., Tiollais P., Bréchot C., Primary liver cancer in hepatitis B surface antigen negative patients : a study of hepatitis B virus genome using polymerase chain reaction. In : Viral hepatitis and liver disease. Hollinger FB., Lemon, SM., Margolis, H Eds, Williams and Wilkins, pp. 605–610, 1990. Kremsdorf D., Thiers V., Garreau F., Tran A., Paterlini P., Gerken, G., Nalpas B., Bréchot C., Variabilité génétique du virus de l'hépatite B et son expression sérologique. In Médecine et Sciences 6, 108–116, 1990. Gerken G., Paterlini P., Manns M., Housset C., Terré S., Dierres H.P. Hess G., Gerlich W.H., Berthelot P., Meyer Zum Buschenfelde K.H., Bréchot C., Polymerase chain reaction (PCR) assay for the evaluation of hepatitis B virus (HBV) viremia in chronic HBV carriers : validation and relation to pre-S and S encoded viral surface proteins. In Hepatology, 13, 158–166, 1991. Paterlini P., Bréchot C., Hepatitis B virus (HBV) and HBsAg negative primary liver cancer. In Digestive Disease and Science, 36, 1122–1129, 1991. Dazza MC, Meneses L.V., Girard PM, Paterlini, P., Villaroel, C., Bréchot C., Larouzé, B., Polymerase chain reaction for detection of hepatitis B virus DNA in HBsAg seronegative patients with hepatocellular carcinoma from Mozambique. Ann. Tropic. Med. and Parasitol., 85, 277–279, 1991. Paterlini, P., De Mitri, S., Martin, C., Munnich, A., Bréchot, C., A TaqI polymorphism in the human cyclin A gene. In Nucleic Acids Research 19, 2516, 1991. Bréchot, C. Kremsdorf, D., Paterlini, P., Thiers, V., Hepatitis B virus DNA in HBsAg negative patients : molecular characterization and clinical implications. J. Hepatol. 13 (suppl.4) : 549–555, 1991. Paterlini, P., Driss, F., Nalpas, B., Pisi, E., Franco, D., Berthelot, P., Bréchot, C., Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from hepatitis B surface antigen-negative paytients : a study based on PCR. In Hepatology, 17: 20–29, 1993. De Mitri, S., Pisi, E. Bréchot, C., Paterlini, P., Low frequency of allelic loss in the cyclin A gene in human hepatocellular carcinomas : a study based on PCR. Liver, 13: 259–261, 1993. Paterlini, P., Suberville AM, Zindy, F., Melle J., Sonnier M., Marie J.P., Dreyfus F., Bréchot, Cyclin A expression in human hematological malignancies : a new marker of cell proliferation. Cancer Res., 53: 235–238, 1993. Debuire, B., Paterlini, P., Pontisso, P., Bréchot, C., May, P., May, E., Low rate of p53 mutations in European hepatocellular carcinomas and hepatoblastomas. Oncogene, 8: 2303–2306, 1993. Lamas, E., Zindy, F., Sobczack, J., Paterlini, P., Wang, J., Chenivesse, X., Henglein B., Bréchot, C. Cycline A et cancer. In Médecine et Science, 9: 676–683, 1993. Buendia, M.A., Paterlini, P., Tiollais, P., Bréchot, C., Hepatocellular carcinoma: molecular aspects. In: Viral Hepatitis. Scientific Basis and Clinical Management. Zuckerman A.J., Thomas H.C. Eds., Churchill Livingstone. pp137–164, 1993. Paterlini P. and Bréchot C., Hepatitis B Virus and Primary Livcer Cancer in Hepatitis B Surface Antigen-Positive and -Negative Patients. In: Liver Cancer: Etiological and Progression Factors. Bréchot C. Ed. CRC Press. pp. 167–190, 1994. Esposito, N., Paterlini, P., Kelly, P., Finidori, J. Expression of two isoforms of the Human Growth Hormone receptor in normal liver and Hepatocarcinoma. In Molecular and Cellular Endocrinology. 103: 13–20, 1994. Paterlini, P., Poussin, K., D'Errico, A., De Mitri, M.S., Kew, M., Grigioni, W., Franco, D., Bréchot, C. Rate of Persistence, Structure, and Expression of HBV Genome in HCC Developing in HBsAg-negative Patients. In: Viral Hepatitis and Liver Diseases. Nishioka, K., Suzuki, H., Mishiro, S., Oda, T., Eds., Springer-Verlag, Tokyo, 757–762, 1994. Paterlini, P., Poussin K., Kew, M., Franco, D., Bréchot, C. Selective accumulation of the X transcript of Hepatitis B virus in patients negative for Hepatitis B Surface antigen with Hepatocellular Carcinoma. In Hepatology, 21: 313–321, 1995. Paterlini, P., Flejou, J-F., De Mitri, M.S., Pisi, E., Franco, D., Bréchot, C. Structure and expression of the Cyclin A gene in Human Primary Liver Cancer. Correlation with Flow Cytometric parameters. J. Hepatol., 23: 47–52, 1995. De Mitri, M.S., Poussin, K., Baccarini, P., D'Errico, A., Grigioni, W., Pisi, E., Bréchot, C., Paterlini, P. HCV-associated liver cancer without cirrhosis. In The Lancet, 345: 413–416, 1995. Nousbaum, J.B., Pol, S., Nalpas, B., Gigou, M., Thiers, V., Okamoto, H., Féray, C., Poussin, K., Paterlini, P., Landais, P., Rumi, M., Colombo, M., Mishiro, S., Wilber, J., Berthelot, P., Bréchot, C. Hepatitis C virus type 1b (II) infection in France and Italy. Ann. Int. Med., 122: 161–168, 1995. Bourdon J.C., D'Errico A., Paterlini P., Grigioni W., May E., Debuire B. p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation. Gastroenterology, 108: 1176–1182, 1995. Delmer A, Tang R, Senamaud-Beaufort C, Paterlini P, Bréchot C, Zittoun R. Alterations of cyclin kinase 4 inhibitor (p16 INK4A/ MTS1) gene structure and expression in acute lymphoblastic leukemias. Leukemia 9: 1240–1245, 1995.