Phosphatidylinositol 3-kinase-related kinase

Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).

Members

The human PIKK family includes six members:

Gene Protein Function ATM ataxia-telangiectasia mutated response to DNA damage ATR ataxia- and Rad3-related " PRKDC DNA-dependent protein kinase catalytic subunit (DNA-PKcs) " MTOR mammalian target of rapamycin (mTOR) nutrient-regulated kinase that controls metabolism and cell growth SMG1 suppressor of morphogenesis in genitalia regulates nonsense-mediated mRNA decay TRRAP transformation/transcription domain-associated protein transcription factor co-activator

Structure

PIKKs proteins contain the following four domains:

N-terminus FRAP-ATM- TRRAP (FAT) domain, kinase domain (KD; PI3_PI4_kinase), PIKK- regulatory domain (PRD), and C-terminus FAT-C-terminal (FATC) domain

References

External links Kinase Family PIKK at WikiKinome.