James Gaffney may refer to:
James Anthony Gaffney (1928–2016), British civil engineer James E. Gaffney (1868–1932), American owner of the Boston Braves James J. Gaffney (1863–1946), American architect James J. Gaffney III (born 1942), American attorney and politician James Gaffney (politician) (1853–1913), Australian politician for the Electoral district of Lyell