Harrison Gray Otis may refer to:
Harrison Gray Otis (publisher) (1837–1917), publisher of the Los Angeles Times Harrison Gray Otis (politician) (1765–1848), American businessman, lawyer, and politician SS Harrison Gray Otis, Liberty ship, commissioned and sunk in 1943
See also Harrison Gray Otis Dwight (1803–1862), American Congregational missionary Harrison G. O. Blake (1818–1876), U.S. Representative from Ohio Harrison Gray Otis House, in Boston, Massachusetts