Defending champion Roger Federer defeated Mardy Fish in the final, 6–7(5–7), 7–6(7–1), 6–4 to win the men's singles tennis title at the 2010 Cincinnati Masters. It was his fourth Cincinnati Masters title, his record-equaling 17th Masters title overall (tying Andre Agassi's tally), and his 63rd career title overall (tying Björn Borg's tally).
Rafael Nadal also made his record 20th consecutive Masters quarterfinal, a streak dating back to the 2008 Canada Masters.
Seeds The top eight seeds receive a bye into the second round.
Main draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Qualifying
Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
External links Main Draw Qualifying Draw