Charles B. Clarke may refer to:
Charles Baron Clarke (1832–1906), British botanist Charles Bailey Clarke (1875–1944), mayor of Portland, Maine, 1918–1921 Charles Boss Clarke (1836–1899), American architect Charles Benjamin Clarke (1844–1891), U.S. representative from Wisconsin
See also Charles Barnett-Clarke, Dean of Cape Town, successor to Henry Alexander Douglas Charles Clarke (disambiguation)