Sapira, Şapira and Šapira are variants of the Jewish Ashkenazi surname Shapiro.

Notable people with the surname include:

Sapira Emmanuel Sapira (1900–1943), Romanian-born Belgian chess master Mircea Sapira, participant at 1937 World Table Tennis Championships – Men's team of Romania Sylvia Sapira, (1908–1981) American harpsichordist Șapira Avraham Șapira, deputy of Guttman Landau, president of the Chișinău Ghetto Committee

Šapira Jankelis Šapira, member of the Vilnius Soviet of Workers Deputies, 1919 Judal Šapira, killed under Stalin (1937 mass execution of Belarusians) or Haim Nachman Shapira (1895-1943), Semitologist and Zionist, lived mainly in Lithuania Leiba Šapira, member of the Lithuanian Central Bureau of the Young Communist League of Lithuania and Belorussia (1919-1920) Zalmenas Šapira, secretary of the communist Lithuanian People's Aid Union

See also Shapiro, surname (article); variants: Chapiro Sapir (surname) Sapiro Schapira Schapiro Shapero Shapira Spear (surname) Spero Spira (surname) Spiro (surname) Szapiro Szpiro Spire – see André Spire Speyer, the German city which Sapira, Spero, etc. are based on Hakham Sapira Synagogue, Tunis