Apalachee may refer to:
People Apalachee people, historical tribe from the Florida Panhandle
Places Apalachee, Georgia, an unincorporated community Apalachee Bay, a bay of the Gulf of Mexico Apalachee Correctional Institution, East Unit, a state prison for men located in Sneads, Florida Apalachee High School, near Winder, Georgia 2024 Apalachee High School shooting, a mass shooting at the school Apalachee Province, an area of what is now the Florida Panhandle historically inhabited by the Apalachee Apalachee River (Alabama), a river in the U.S. state of Alabama Apalachee River (Georgia), a river in the U.S. state of Georgia
Other Apalachee (horse), a thoroughbred racehorse Apalachee language, an extinct Muskogean language Talimali Band of Apalachee Indians, a nonprofit organization in Louisiana