Charles Woodruff may refer to:
Charles Woodruff (archer) (1846–1927), American Olympic archer Charles Armijo Woodruff (1884–1945), 11th Governor of American Samoa Charles E. Woodruff, (1860-1915), American military surgeon, sanitarian, and writer. Charles Woodruff (general) (1845–1920) Charlie Woodruff (1884–1943), English footballer
See also Charles Woodruff House (disambiguation) two National Register of Historic Places locations