Samuel Hopkins or Sam Hopkins may refer to:
Samuel Hopkins (inventor) (1743–1818), American inventor who was awarded the first US patent for a process to refine potash Samuel Hopkins (theologian) (1721–1803), American clergyman who formulated a religious system called Hopkinsism or Hopkinsianism Samuel Hopkins (congressman) (1753–1819), United States Congressman from Kentucky Samuel I. Hopkins (1843–1914), U.S. Representative from Virginia Samuel M. Hopkins (1772–1837), United States Representative from New York Sam Hopkins (rugby league) (born 1990), English rugby league footballer Lightnin' Hopkins (Sam John Hopkins, 1912–1982), American blues guitarist Sam Hopkins (artist) (born 1979), Artist whose work is rooted in Kenya
See also Samuel Hopkins House, a historic home in Suffolk County, New York