NKC is a three letter abbreviation that may refer to:
IATA airport code for Nouakchott–Oumtounsy International Airport National Kennel Club, all-breed dog registry in the United States Nat King Cole, American jazz singer/musician NDR-Klein-Computer, a German computer Northwest Kidney Centers, outpatient hemodialysis treatment center Natural killer cell, cell involved in the innate immune system National Knowledge Commission, Indian Commission set up by Manmohan Singh