Trypanosome may refer to:
Trypanosomatida, a biological order within Kinetoplastida Trypanosoma, a genus within Trypanosomatida whose members are often referred to as trypanosomes Trypanosoma brucei, a major human pathogen that causes sleeping sickness Trypanosoma cruzi, a major human pathogen that causes Chagas disease A morphological class of trypanosomatid with a flagellum laterally attached to the cell body