Frederick Muhlenberg (1750–1801) was the first Speaker of the U.S. House of Representatives.

Frederick Muhlenberg may also refer to:

Frederick Augustus Muhlenberg (1887–1980), architect, Army officer and U.S. congressman from Pennsylvania Frederick Augustus Muhlenberg (educator) (1818–1901), president of Muhlenberg College

See also Portrait of Frederick Muhlenberg, portrait of Frederick Muhlenberg (1750–1801) by Joseph Wright