Neacșu is a Romanian surname and sometimes a male given name.
Notable people with the surname include:
Ion Neacșu (1930–1988), Romanian footballer Ionelia Neacșu (married name Ionelia Zaharia), Romanian rower, competed in the 2008 Summer Olympics Lupu Neacșu, the author of Neacșu's letter Marilena Neacșu, Romanian artistic gymnast Mihaela Neacșu, Romanian middle-distance runner, competed in the 2008 Summer Olympics Nicolae Neacșu (1924–2002), Romani violinist Robert Neacșu, Romanian footballer
As a male given name, it was used by:
Neacșu Șerbu (born 1928), Romanian boxer