The Big Eight Conference was an NCAA Division I-A athletic conference that operated from 1907 to 1996.
Big Eight Conference may also refer to:
Big Eight Conference (California), a junior college athletic conference that operated from 1950 to 1962 Big 8 Conference (California), a junior college athletic conference Big Eight Conference (IHSAA), Indiana and Illinois, a high school athletic conference Big Eight Conference (Iowa), a defunct high school athletic conference Big 8 Conference (Missouri), a high school athletic conference WIAA Big Eight Conference, Wisconsin, a high school athletic conference