Sempronius may refer to:
Sempronius, the nomen of the Roman gens Sempronia Sempronius, a character in the play The Apple Cart Sempronius, New York Sempronius, Texas Sempronius Stretton, a British Army officer and artist Sempronius H. Boyd, U.S. Congressman from Missouri and U.S. Civil War Colonel. Sempronius, a fictional Roman senator in Cato, a Tragedy by Joseph Addison