ISS is the International Space Station, a modular space station in low Earth orbit.

ISS may also refer to:

Organizations Information Systems & Services, a former part of the UK Ministry of Defence Institute for Science and Society, an academic department at the University of Nottingham, England Institute for Security Studies, a think tank in South Africa

Institute of Social Studies, an international institute in The Hague, the Netherlands International Social Service, a charitable, non-governmental organisation Internal Security Service, national security intelligence agency of Oman Istituto Superiore di Sanità, the Italian National Institute of Health Intercollegiate Socialist Society, an American political youth organization (1905–1921)

Businesses ISS A/S, a Danish service company Institutional Shareholder Services, a proxy advisory firm Internet Security Systems, a security software vendor

Arts, media, and entertainment I.S.S. (film), an American science fiction thriller film International Staff Songsters, the flagship choir of the Salvation Army Incredible Shrinking Sphere, a 1989 video game International Superstar Soccer, a video game series ISS (2000 video game) Idea Star Singer, a Malayalam music reality show by Asianet TV Imperial Star Ship, a fictional spaceship designation prefix in Star Treks Mirror Universe

Education ISS International School, an international school in Singapore In-school suspension, a form of discipline used in some schools Instituto San Sebastián Yumbel, a school in Chile

Science and technology Ion scattering spectroscopy, or low-energy ion scattering, a materials analysis method Imaging Science Subsystem, Cassini–Huygens space probe instruments Instruction set simulator, a computer program that simulates a processor International Seismological Summary, an earthquake catalog Input Shaft Speed, the rotational speed of the input shaft in a vehicle

Medicine Idiopathic short stature, an unexplained short stature Injury Severity Score International Staging System, for the severity of multiple myeloma

Other uses IShowSpeed, an American YouTuber and streamer (born 2005) Independent Subway System, a former rapid transit rail system in the United States Islamic State in Somalia, a faction of the Islamic State of Iraq and the Levant ISS Hockey (International Scouting Services), an ice hockey scouting service Air Italy (2005–2018), a former Italian airline (ICAO code: ISS)

See also Isis (disambiguation) IIS (disambiguation)