Botana is a Spanish surname. Notable people with the surname include: Adam Botana, American politician Antia Botana, Spanish and American physicist Ismael Prego Botana, Spanish YouTuber better known as Wismichu Natalio Botana (1888–1941), Uraguayan journalist Raúl Damonte Botana (1939–1987), Argentine writer better known as Copi Uxía Martínez Botana (born 1988), Spanish musician