Antony and Cleopatra is a play by William Shakespeare.

Antony and Cleopatra may also refer to:

Historical Figures Mark Antony, member of the Triumvirate of Rome Cleopatra, Queen of the Ptolemaic Kingdom of Egypt from 51 to 30 BC

Books Antony and Cleopatra (novel), a 2007 novel by Colleen McCullough Antony and Cleopatra, a 2010 history book by Adrian Goldsworthy

Film and television Antony and Cleopatra (1908 film), a film starring Maurice Costello and Florence Lawrence Antony and Cleopatra (1913 film), a 1913 Italian film starring Amleto Novelli and Gianna Terribili-Gonzales Antony and Cleopatra (1959 film), an Australian television play Antony and Cleopatra (1972 film), a film starring Charlton Heston and Hildegarde Neil Antony and Cleopatra (1974 TV drama), a television version of a Royal Shakespeare Company production starring Richard Johnson and Janet Suzman Antony and Cleopatra, a 1981 television version produced as part of the BBC Television Shakespeare starring Colin Blakely and Jane Lapotaire

Music Antony and Cleopatra (musical duo), a British / Australian electronic duo, with musicians Anita Blay and Alexander Burnett

Theatre Antony and Cleopatra (Barber), a 1966 opera by Samuel Barber Antony and Cleopatra (2022 opera), a 2022 opera by John Adams