U.S. Highway 65 (US 65) is a part of the United States Numbered Highway System that spans from Clayton, Louisiana to Albert Lea, Minnesota. Within the state of Louisiana, the highway travels from the national southern terminus at US 425/LA 15 in Clayton to the Arkansas state line north of Lake Providence.

US 65 parallels the west bank of the Mississippi River through the northeastern portion of Louisiana. It traverses four parishes. Newellton, Tallulah, and Lake Providence, which constitute the largest towns along the route. In Tallulah, US 65 has a junction with Interstate 20, the principal highway across northern Louisiana. I-20 connects to a bridge across the Mississippi River at Vicksburg, Mississippi, which is the only automobile crossing between Greenville and Natchez.

The Natchez–Vidalia Bridge was part of US 65 prior to 2005 when the designation was replaced by that of US 425 between Clayton and Natchez. During the years 1936 to 1951, US 65 was more than double its present length as it overlapped US 61 from Natchez south to New Orleans.

Route description Clayton to Tallulah From the south, US 65 begins at a junction with the concurrent US 425/LA 15 in Clayton, a small town in northern Concordia Parish. US 425/LA 15 travels along a widely spaced four-lane one-way pair through town en route to its immediate destinations of Ferriday and Sicily Island. US 65 heads northeast from this junction as an undivided two-lane highway and crosses into Tensas Parish. An intersection with LA 568 at Azucena leads to Lake St. John, an oxbow lake of the nearby Mississippi River. Soon afterward, US 65 passes through the western edge of Waterproof, the first of several towns on the route located along the river's west bank. Several minor state highways, such as LA 3209 (Church Lane), connect US 65 with Waterproof's main street.

Continuing northeast, US 65 bypasses St. Joseph, the parish seat. However, a junction with LA 128 at Avondale provides access to the town. Just north of St. Joseph, US 65 passes to the west of Lake Bruin, another oxbow lake. Points of interest in this area include Lake Bruin State Park and the Winter Quarters State Historic Site. US 65 proceeds through the western edge of Newellton, a town situated on Lake St. Joseph, a third oxbow lake of the Mississippi River. LA 4 (Verona Street) leads into the center of town and also connects to the city of Winnsboro in neighboring Franklin Parish. After passing through Somerset, US 65 crosses into Madison Parish at a point known as Quimby.

US 65 winds gently through southern Madison Parish for before entering Richmond, a small village adjacent to the parish seat, the city of Tallulah. The highway passes through an interchange with I-20 at exit 171, connecting with Vicksburg, Mississippi and Monroe, Louisiana. Entering Tallulah proper, US 65 crosses a bridge over Walnut Bayou and curves northeast onto the undivided four-lane thoroughfare of Bayou Drive, flanked by the bayou and a residential neighborhood.

Tallulah to Arkansas state line Heading into the business section of Tallulah, US 65 divides onto the one-way pair of Cedar and Chestnut Streets, thus becoming a divided four-lane highway briefly. One block after crossing the Kansas City Southern Railway (KCS) line, the route intersects US 80 (East Green Street), which serves local traffic along the I-20 corridor. The travel lanes of US 65 converge as the highway heads out of Tallulah and begins to follow alongside the Delta Southern Railroad (DSRR) tracks.

North of Tallulah, US 65 travels through an extended stretch of open farmland. Immediately after crossing into East Carroll Parish, the highway passes through the tiny community of Sondheimer. At a point known as Alsatia, US 65 intersects LA 580, which heads west toward Poverty Point, a UNESCO World Heritage Site located near the village of Epps. Continuing due north, US 65 passes through such rural points as Transylvania and Hollybrook before entering the parish seat, Lake Providence, which is located on an oxbow lake of the same name. After crossing the corporate limits, US 65 immediately divides onto the one-way pair of Sparrow and Scarborough Streets. In the center of town, the route turns left onto Lake Street and becomes an undivided two-lane highway again.

US 65 takes on the character of a scenic drive as it travels out of town hugging the shore of Lake Providence. Along this stretch is a junction with LA 2 at its eastern terminus, connecting with Oak Grove and Bastrop. Departing from the lake shore, US 65 curves due north and rejoins the straight alignment of the DSRR tracks for its final in Louisiana. The highway crosses into the state of Arkansas just north of Gassoway and proceeds toward Eudora en route to Little Rock.

Route classification and data US 65 alternates between a rural and urban principal arterial over the course of its route, as determined by the Louisiana Department of Transportation and Development (La DOTD). Daily traffic volume in 2013 peaked at 10,400 vehicles in Tallulah. The remainder of the route generally averaged between 2,200 and 5,800 vehicles with a low of 1,840 reported near the Arkansas state line. The posted speed limit is for most of the route but is reduced as low as within corporate limits.

Within Louisiana, the entirety of US 65 serves as part of a National Scenic Byway known as the Great River Road. This byway consists of a network of roads that parallel the Mississippi River through ten states. The Louisiana portion encompasses several state highways, extending as far south as Venice near the mouth of the river.

History Original route and southern extension US 65 was designated in November 1926 as one of the inaugural routes of the numbered U.S. Highway system. It was routed entirely along the existing State Route 3, one of Louisiana's original state highways created only five years earlier. Known as the Scenic Highway, it paralleled the west bank of the Mississippi River through the northeastern portion of the state and served as an important connection between the capital cities of Louisiana and Arkansas. Like Route 3, US 65 once extended further south to Vidalia, a small city opposite Natchez, Mississippi. At the time, a ferry carried the route across the river to connect with US 61, the principal route to New Orleans.

In 1934, the US 65 Lakes-to-Gulf Highway Association was formed to promote travel between Minneapolis–St. Paul and New Orleans. One of its principal objectives was having US 65 officially extended from Natchez south to New Orleans. Two years later, the designation was applied to the entire route of US 61 south of Natchez as it traveled back into Louisiana and passed through Baton Rouge en route to its terminus in New Orleans. This change extended US 65 a distance of and allowed motorists to follow a single highway number from New Orleans to Little Rock, Arkansas. It came three years after US 61 was almost entirely relocated between New Orleans and Baton Rouge from its original path alongside the winding Mississippi River onto the modern, streamlined Airline Highway. This routing remained in effect until 1951 when the Louisiana Department of Highways eliminated such lengthy U.S. Highway concurrencies, and the southern terminus of US 65 was moved back to Natchez.

Early improvements and paving When originally designated in 1926, US 65 was a gravel-surfaced highway throughout its route in Louisiana. Hard-surfacing of the highway was promised by Huey P. Long during his successful 1928 gubernatorial campaign and also by state senator and Louisiana Highway Commission chairman, O.K. Allen. By 1930, the perceived lack of initiative in fulfilling this promise drew much criticism from the pair's political opponents based in northeastern Louisiana. However, in October of that year, bidding was opened for 31 contracts in the "largest letting for road and bridge construction in the history of the state" up to that time. This included the paving of an stretch of US 65 in East Carroll Parish between Lake Providence and Transylvania that was completed the following year. The remainder of the highway south to Vidalia was provided for soon afterward and was completed by the summer of 1932.

This left only the portion between Lake Providence and the Arkansas state line to be hard-surfaced, which was not carried out until the spring of 1938. While the earlier paving projects had closely followed the established gravel alignment, this last project straightened the highway north of Lake Providence by following the Missouri Pacific Railroad line (now the Delta Southern Railroad). The original route had hugged the shore of two oxbow lakes known as Lake Providence and Old River between Highland and Millikin.

Natchez–Vidalia Bridge In 1940, US 65 received a major improvement when the first Natchez–Vidalia Bridge was constructed across the Mississippi River, replacing a ferry service that had existed for over a century. The bridge's construction was primarily advanced by the state of Mississippi and the local governments of Adams County and the city of Natchez. The project was financed through matching loans totaling almost $3,800,000 from two New Deal programs, the Public Works Administration and the Reconstruction Finance Corporation, which were approved in June 1936 and October 1938, respectively. A toll equaling that of the existing ferry would be charged only until the loans were repaid. Under this arrangement, the Louisiana Legislature aided the project by passing a special bill in June 1938 allowing the bridge to be exempt from state taxes. The location chosen for the new bridge was nearly the same as the ferry landing on the Louisiana side.

Construction began in December 1938, and the bridge was officially opened to traffic with great ceremony on September 26, 1940. US 65 shared the new bridge with US 84, which had been extended into Louisiana in 1934. The cantilevered through truss structure was designed by the engineering firm of Ash, Howard and Needles, which had been responsible for the US 80 bridge at Vicksburg a decade earlier. In 1952, the bridge's debts were paid off, and the toll was eliminated on the twelfth anniversary of its opening.

While the Natchez–Vidalia Bridge was under construction, virtually the entire town of Vidalia consisting of about 1,000 citizens, was demolished and rebuilt several blocks away from the river bank. This allowed for the construction of a setback levee that would enable the widening of the river at Natchez and reduce the pressure of the current on its banks, which was cited as a great hazard to both towns. The moving of Vidalia increased the construction cost of the bridge from its original estimate of $2,500,000 to $4,000,000.

Route relocation and further improvements