SMDC refers to the United States Army Space and Missile Defense Command.
SMDC may also refer to:
St. Mary's/Duluth Clinic Health System in Duluth, Minnesota Saskatchewan Mining Development Corporation, a former provincial crown corporation in Saskatchewan, Canada SM Development Corporation, a subsidiary of Philippine company SM Investments Sunshine Maritime Development Corporation, owner of the oil tanker involved in the 2006 Guimaras oil spill Shalamar Medical and Dental College, Lahore, Pakistan Sharif Medical and Dental College, Lahore, Pakistan