Karen Johnson may refer to:
Karen Johnson (producer), American television soap opera director, producer, writer, and editor Karen Johnson (violinist), American violinist Karen Johnson (Arizona politician), Arizona politician Karen Johnson (Florida politician) Karen Johnson (sailor) (born 1962), Canadian Olympic sailor Karen C. Johnson (born 1955), research professor in Medicine, University of Tennessee Health Science Center Karen B. Johnson (1942–2019), mayor of Schenectady, New York Karen Johnson (scientist), British geologist
See also Karen Johnston, American singer-songwriter better known as Michelle Shocked