Chloropyridines are a group of aryl chlorides consisting of a pyridine ring with chlorine atoms as substituents.
Chloropyridines include: 2-Chloropyridine 3-Chloropyridine 4-Chloropyridine 2,6-Dichloropyridine
Production Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine.
2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride. Uses Chloropyridines are important intermediates to pharmaceuticals and agrochemicals. A major use of 2-chloropyridine is the production of production of the fungicide pyrithione. Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of cephalosporin antibiotics.
4-Chloropyridine is a precursor to ofornine & besipirdine.
See also Bromopyridine Fluoropyridine Iodopyridine
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