PRL may refer to:
Places Polish People's Republic (Polska Rzeczpospolita Ludowa), 1952–1989
Business and enterprises Pakistan Refinery Limited, a refinery in Karachi Penn Eastern Rail Lines, reporting mark Polo Ralph Lauren, an American clothing and lifestyle brand
Computing and technology Preferred Roaming List, in CDMA phones The PRL Project at Cornell University which maintains the Nuprl mathematical proofing toolset. Proportional reduction in loss, a measure of reliability Protocol-relative link, URLs which do not specify a protocol
Political parties Liberal Reformist Party (Dominican Republic) Parti Réformateur Libéral, a former political party in Belgium Party of the Radical Left (Partija radikalne levice), a political party in Serbia Republican Party of Liberty, a conservative political party in France, 1945–1951
Other organisations Premiership Rugby Limited, the organising body of Premiership Rugby
Science and healthcare Physical Research Laboratory, India Physical Review Letters, a scientific journal PRL-8-53, Nootropic research chemical Prolactin, a hormone MSU-DOE Plant Research Laboratory in Michigan, United States
Other Parramatta Rail Link, a formerly proposed railway project in Sydney, Australia