Regis or Régis is a surname. Notable persons with that surname include:
Albert Regis (born 2003), American football player Balthasar Regis (died 1757), Canon of Windsor Cyrille Regis (1958–2018), English association football player Dave Regis (born 1964), English association football player David Regis (born 1968), French-American association football player Ed Regis (author) (born 1944), American author and educator Hazel-Ann Regis (born 1981), Grenadian sprinter Jean-Baptiste Régis (died 1738), French Jesuit missionary John Regis (athlete) (born 1966), English sprinter Johannes Regis (c. 1425 – c. 1496), Franco-Flemish composer John Francis Regis (1597–1640), French Jesuit and Roman Catholic saint Louis-Marie Régis (1903–1988), Canadian philosopher, theologian, and scholar Miles Regis (born 1967), American-Trinidadian multi-media artist Pierre-Sylvain Régis (1632–1707), French philosopher Robert Regis (born 1967), English association football player Rogério Fidélis Régis (born 1976), Brazilian football player Sheryn Regis (born 1980), Filipina pop singer and composer Simone Régis, Brazilian fashion model and beauty queen