Cambiaso is an Italian surname. Notable people with the surname include:
Adolfo Cambiaso (born 1975), Argentine polo player Andrea Cambiaso (born 2000), Italian football player Luigi Cambiaso (1895–1975), Italian gymnast Luca Cambiaso (1527–1585), also known as Cambiasi, Italian Renaissance painter Esteban Cambiasso (born 1980), Argentine football midfielder Nicolás Cambiasso (born 1978), Argentine football player, elder brother of Esteban Cambiasso