Microtubule-associated tyrosine carboxypeptidase 1 is an enzyme that in humans is encoded by the MATCAP1 gene (previously KIAA0895L). It is a protease, which removes a tyrosine from the (C-terminal) end of cytoskeleton proteins called alpha tubulin. In this way, it helps regulate the function and dynamics of alpha tubulin.
Gene
MATCAP1 is located at q22.1 on chromosome 16 of the human genome.Genecards bin/cards/carddisp.pl?gene=KIAA0895L&search=KIAA0895L Its genomic DNA consists of 8,379 base pairs.NCBI MATCAP1 is located between EXOC3L and E2F4 on the right, and NOL3 and HSF4 on the left.NCBI Entrez Gene The promoter for MATCAP1 is located on chromosome 16 and spans 67217367-67218383bp.UCSC Genome Bioinformatics
MATCAP1 was first documented by the Mammalian Gene Collection Program Team in 2002. There are several patents on MATCAP1, two of those being patent US 6943241 and patent EP1308459. BLAST (Basic Local Alignment Search Tool)
Species distribution
MATCAP1 orthologs can be found in all mammals.KEGG It is not found in plants, archaea, or fungi. MATCAP1 has a single paralog, known as MATCAP2.KEGG
The known orthologs of MATCAP1 are listed below:SDBC(San Diego Supercomputer Center Biology Workbench)
Chimpanzee – LOC741288 Rhesus monkey – LOC696623 Dog – LOC489765 Horse – LOC100053028 Giant panda – PANDA_006923 Cow – LOC512420 Norway rat – LOC688736 Zebra finch – LOC100223241 Chicken – LOC415660 Mouse – LOC74356 Opossum – LOC100019983 Puffer fish – Unnamed Sea squirt – LOC100177006 Platypus – LOC100078127 Zebrafish – LOC562097 Frog – LOC100135412 Sea urchin – KIAA0895 Ciliated protozoa – TTherm_01042050 Plasmodium – PY05482 Trichoplax adherens – TRIADDRAFT_62861 Kordia – KAOT1_03617
Structure
MATCAP1 is composed of 471 amino acids (53.5kDa).Genecards bin/cards/carddisp.pl?gene=KIAA0895L&search=KIAA0895L A proline-rich region was also revealed at 14-65 amino acids.KEGG(Kyoto Encyclopedia of Genes and Genomes) There is also an area of low complexity at 2913-2917 bp in the 3’ UTR region. There is a conserved domain of unknown function, known as DUF1704, located at 1390-2083 bp.BLAST(Basic Local Alignment Search Tool)
Predicted post translational modifications
The following is a list of predicted post translational modifications found for MATCAP1.Swiss Institute of Bioinformatics, ExPASy These are predicted in all mammalian orthologs in the public sequence database.
type of modification residues modified O-GlaNAc glycosylation T19, T96, T174, and T314 Ser, Thr, and Tyr phosphorylation S16, S20, S23, S31, S80, S82, S85, S88, S136, S349, S419, T96, T112, T125, T284, T379, T406, Y84, Y360, and Y420 Kinase-specific phosphorylation T96 and T125
Tissue distribution
MATCAP1 is expressed in many tissues of the body such as brain, testis, mammary glands, bladder, and the eye.Genecards
Clinical significance
MATCAP1 has been shown to be up regulatedNCBI GEO (National Center for Biotechnology Information Gene Expression Omnibus) in lymphoblastoid cells from males with autism that is caused by an expansion of a CGG repeat in the promoter region of the fragile X mental retardation 1 gene located at Xq27.3 as well as in cells with a 15q11-q13 mutation.
Notes and references