Fanetizole is a drug that has immunoregulating activity.Rocklin RE, Hemady Z, Matloff S, Kiselis I, Lima M. Correction of an in vitro immunoregulatory defect in atopic subjects by the immunostimulating drug fanetizole mesylate (CP-48,810). Int J Immunopharmacol. 1984;6(1):1-8. doi: 10.1016/0192-0561(84)90028-6. PMID: 6233230.
Synthesis Reaction of β-phenethylamine (1) with ammonium thiocyanate (2) gives the thiourea (3). Treatment of that product with phenacyl bromide (4) produces fanetizole (5).Joseph G. Lombardino, (1981 to Pfizer Corp SRL).
Other syntheses:Pastre, Julio C.; Browne, Duncan L.; O’Brien, Matthew; Ley, Steven V. (2013). "Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia". Organic Process Research & Development. 17 (9): 1183–1191. doi:10.1021/op400152r.Lin, Pei-Ying; Hou, Rei-Sheu; Wang, Huey-Min; Kang, Iou-Jiun; Chen, Ling-Ching (2009). "Efficient Synthesis of 2-Aminothiazoles and Fanetizole in Liquid PEG-400 at Ambient Conditions". Journal of the Chinese Chemical Society. 56 (3): 455–458. doi:10.1002/jccs.200900068.
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