William S. Smith may refer to:
William Stephens Smith (1755–1816), United States Representative from New York Sir William Sidney Smith (Royal Navy officer), British admiral William Saumarez Smith (1836–1909), Australian Anglican archbishop William Sooy Smith (1830–1916), American Civil War general William Sidney Smith (assemblyman), New York politician William S. Smith Jr. (born 1947), former president of the Association of Universities for Research in Astronomy (AURA)
See also William Smith (disambiguation)