DALT

Diallyltryptamine (DALT), also known as N,N-diallyltryptamine, is a tryptamine derivative which has been identified as a designer drug.

Use and effects According to Alexander Shulgin in his book TiHKAL (Tryptamines I Have Known and Loved), the dose of DALT is greater than 40mg orally and its duration is unknown. Its effects were not described. Per Stephen Szara and colleagues in much earlier publications however, DALT and other extended N,N-dialkyltryptamines produce similar effects to dimethyltryptamine (DMT) but are longer-lasting, with durations of up to 3hours.

Interactions

Pharmacology Pharmacodynamics + Target Affinity (Ki, nM) 5-HT1A 100 5-HT1B >10,000 5-HT1D 689 5-HT1E 378 5-HT1F 5-HT2A 701 5-HT2B 61 5-HT2C 385 5-HT3 >10,000 5-HT4 5-HT5A >10,000 5-HT6 1,718 5-HT7 >10,000 α1A 1,663 α1B 1,369 α1D >10,000 α2A 124 α2B 305 α2C 901 β1–β3 >10,000 D1, D2 >10,000 D3 672 D4, D5 >10,000 H1 127 H2–H4 >10,000 M1–M5 >10,000 I1 σ1 101 (rat) σ2 356 (rat) , >10,000 2,477 150 (Ki) 1,121 (Ki) 1,406 (Ki) Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs:

The receptor interactions of DALT have been studied. The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.

Chemistry DALT has been used as an intermediate in the preparation of radiolabeled diethyltryptamine (DET).

Synthesis The chemical synthesis of DALT has been described.

Analogues Analogues of DALT include 4-HO-DALT, 4-AcO-DALT, 5-MeO-DALT, methylallyltryptamine (MALT), propylallyltryptamine (PALT), and isopropylallyltryptamine (iPALT), among others.

History DALT was first described in the scientific literature by Stephen Szara and colleagues by 1962.

Society and culture Legal status Canada DALT is not an explicitly nor implicitly controlled substance in Canada as of 2025.

United States DALT is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

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