Šafařík (feminine: Šafaříková) in a Czech surname. Šafárik (feminine: Šafáriková) in a Slovak surname. Notable people with the surname include:
Michal Šafařík (1977–2020), Czech ice hockey player Pavel Jozef Šafárik (1795–1861), Slovak philologist, poet, Slavist and historian Vojtěch Šafařík (1829–1902), Czech chemist
See also Šafář 8336 Šafařík, a main belt asteroid Šafařík (crater), a crater on the Moon