Milone is a surname. Notable people with the surname include:
Anthony Michael Milone (1932–2018), American Roman Catholic bishop Cesare Ferro Milone (1880–1934), Italian painter Eugene Milone (born 1939), American astronomer Giuseppe Milone (born 1949), Italian sailor Nathan Milone (born 1994), Australian rugby league footballer Paul Milone (born 1956), American soccer player Tommy Milone (born 1987), American baseball player Libero Milone,(born 1949-), Auditor General of the Vatican from 2015 to 2017